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Expression. Mann-Whitney U test was used to analyze statistical differencespatients (Fig. 4a and b), whereas PFS for first-line chemotherapy of the three subtypes of patients did not differ significantly (Additional file 5: Figure S4b). Next, we categorized all colorectal tumors into a high and low miR-193a-3p expression group using the median value in all samples as a cut-off point. We found that
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Ed to be associated with a lower RR (24 vs. 42 ; Additional file 1: Table S2) for anti-EGFR therapy. Since our results showed that miR-193a-3p was identified as a mutant-BRAF-specific miRNA, the worseoutcome of colorectal cancer patients with the downregulation of miR-193a-3p from anti-EGFR therapy may be confounded by the BRAF-mutation status. To avoid this possibility, we analyzed PFS for anti-
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Ional role of miRNAs in colorectal cancer, such as miRNA-21 (miR-21), miR-31, miR-34b/c, miR-135b, miR-137, miR-143, miR-145, miR-148a, miR200, and miR-203 [21?9]. Moreover, a few reports have focused on the relationship between BRAF mutations and some miRNA alterations in other cancers, although their miRNA expression profiles were not similar [30?2]. However, whether the BRAF-mutant-specific miR
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Ional role of miRNAs in colorectal cancer, such as miRNA-21 (miR-21), miR-31, miR-34b/c, miR-135b, miR-137, miR-143, miR-145, miR-148a, miR200, and miR-203 [21?9]. Moreover, a few reports have focused on the relationship between BRAF mutations and some miRNA alterations in other cancers, although their miRNA expression profiles were not similar [30?2]. However, whether the BRAF-mutant-specific miR
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Ional role of miRNAs in colorectal cancer, such as miRNA-21 (miR-21), miR-31, miR-34b/c, miR-135b, miR-137, miR-143, miR-145, miR-148a, miR200, and miR-203 [21?9]. Moreover, a few reports have focused on the relationship between BRAF mutations and some miRNA alterations in other cancers, although their miRNA expression profiles were not similar [30?2]. However, whether the BRAF-mutant-specific miR
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Collagen implant, however, the implant was completely substituted by the newly regenerated tissue that was morphologically and biochemically comparable to intact tendons. No signs of tissue rejection were seen and the collagen implant was well tolerated by the animals so that their hematological parameters were normal at 120 days after injury. All animals were clinically normal and no unexpected d
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Collagen implant, however, the implant was completely substituted by the newly regenerated tissue that was morphologically and biochemically comparable to intact tendons. No signs of tissue rejection were seen and the collagen implant was well tolerated by the animals so that their hematological parameters were normal at 120 days after injury. All animals were clinically normal and no unexpected d
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Fingerprints were searched with MASCOT 1.8 (Matrix Science LTD, U.K.) against the following publicly available databases:NCBInr [19] MSDB [20] Ensembl zebrafish peptide database [21] TIGR zebrafish gene index [22]MASCOT search parameters +/- 150 ppm peptide mass tolerance, enzyme specificity: trypsin, 1 missed cleavage tolerated, fixed modifications: carbamidomethylSilver staining was performed as